Six Celebs Who Prove Trump Derangement Syndrome Has No Cure

Few things unite Hollywood quite like a shared hatred for Donald Trump. 

Since his rise from real estate mogul to reality TV star to the 45th president of the United States, Trump has lived rent-free in the heads of some of the entertainment world’s loudest voices. And even now, several months into Trump’s second term in office, certain celebrities still can’t fathom or accept reality. 

Whether it’s red carpet rants, late-night show meltdowns, or rambling podcast diatribes, these stars have made Trump-hating a major part of their identities. Like so many other leftists, they suffer from Trump Derangement Syndrome, or TDS.

Robert De Niro

No list of TDS-suffering celebrities would be complete without Robert De Niro, a man who’s practically turned Trump hatred into a second career.

Once regarded as one of the greatest actors of his generation, De Niro, 82, has turned Trump-bashing into his magnum opus. He’s gone on record calling Trump a “wannabe gangster” and a “monster.” 

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Recently, the “Raging Bull” actor indicated that the president wasn’t even a human.

“Trump does not understand anything about humanity,” De Niro said. “He has no empathy. I don’t know what he is, but he’s an alien, and he wants to hurt this country. It’s something deeply psychological in him. He wants to hurt people.”

While commenting about the No Kings protests, the actor insisted that Trump would not leave office at the end of his term. “We cannot let up because [Trump] is not going to leave the White House. He does not want to leave the White House; he will not leave the White House. Anybody who thinks, ‘Oh, he’ll do this, he’ll do that,’ is just deluding themselves.”

De Niro’s TDS is nothing new. In a 2016 video that went viral, the actor ranted, “He’s so blatantly stupid. He’s a punk, he’s a dog, he’s a pig…I’d like to punch him in the face.” 

In May 2024, he told MSNBC that Trump is “worse than Mussolini” and “wants to destroy democracy.” 

Kathy Griffin

One person giving De Niro a run for his money on the “who’s the biggest TDS culprit of them all” list is comedian Kathy Griffin, a woman so besieged with hate that she ruined her career for the sake of putting her TDS on full display.

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In 2017, the D-list celeb and plastic surgery expert infamously posed for a photo holding what appeared to be the bloody, severed head of Donald Trump. The image was so disturbing that even her Hollywood peers, no fans of Trump themselves, distanced themselves from her. 

“I’m not afraid of Donald Trump,” she said later, also accusing Trump of personally attacking her. “What’s happening to me has never happened, ever in the history of this great country, which is that a sitting president of the United States and his grown children and the first lady are personally, I feel, personally trying to ruin my life forever.”

After committing career suicide, you’d think Griffin would show an ounce of remorse or introspection. Instead, she’s spent the years since doubling down. 

On her podcast, she continues to rant about Trump and his supporters. Earlier this month, Griffin took her derangement to new heights by claiming that Trump stole the election.

“People are calling this protest the No Kings Day, because Trump thinks he’s a f***ing king,” Griffin said on an episode of her YouTube show, titled “The Un-Cancelation of Kathy Griffin.” 

“And you know he’s not. He’s barely a president,” she went on. 

“I’m going to say something that’s going to get me in trouble,” Griffin said before saying it may make her seem “crazy,” but she doesn’t believe Trump “won in a free and fair election.”

The comedian said she believed Trump’s win wasn’t legit because Elon Musk was “handing out million-dollar checks to people to vote for Trump,” calling the supposed act “unconstitutional and illegal.”

“He’s, like, a fake genius…he’s a professional Nazi, in my humble opinion,” Griffin said about Musk.

The D-lister also said it was “suspicious” that Trump won all seven swing states, a feat which ”has never happened in the history of the U.S.,” she claimed.

Whoopi Goldberg

Then there’s Whoopi Goldberg, who has made “The View” her own personal soapbox against Trump, whose name she refuses to utter — instead opting for terms like “the man in the White House” or “you know who” — despite being totally obsessed with him. 

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Day after day, the actress and panelist rails against the president and every decision he makes. 

Goldberg has called out Trump for almost every move he made and even alluded to leaving the country if he won, though she later claimed she never said that.

Her wrath isn’t just for Trump himself, but extends to his supporters as well. The comedian took a page from former Democratic nominee Hillary Clinton’s “basket of deplorables” playbook, saying on “The View” that she can’t even talk to people who support the president.

Goldberg also made it clear that her disdain extends to the entire half of the country that voted for him.

“I think this is beyond Democrats and Republicans,” Goldberg said. “It’s hard to talk to people who support people who think you don’t matter in the country…When you support THAT person…when we find the stuff that we agree on, that’s what we do. When we find the stuff that is disagreeable to the majority, now, I didn’t find anything of interest for me in Project 2025. I didn’t feel like this is geared to us as a nation, I felt it was geared to very specific folks and that bothered the poo out of me.”

Rob Reiner

And she’s not the only one with a singular focus of hatred. Director Rob “Meathead” Reiner, best known for “When Harry Met Sally” and “The Princess Bride,” has turned his Twitter feed into a never-ending Trump rant. Reiner once called Trump a “sociopath” who is “sick in the head” and regularly declares that “our democracy is being taken away from us.” 

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Reiner frequently vented his rage on Twitter until Trump won the 2024 election, at which point he left X completely. His ire isn’t confined to social media, though. The Hollywood director has appeared on MSNBC to warn that Trump is ushering in the end of the country as we know it.

“Make no mistake: We have a year before this country becomes a full-on autocracy and democracy completely leaves us,” he warned in October. 

Larry David

Even Larry David, the king of curmudgeons, couldn’t resist joining the chorus. 

The “Curb Your Enthusiasm” star, who has built a career on playing a fictionalized version of his own neuroses, wrote a whole op-ed for The New York Times criticizing Bill Maher for daring to dine with Trump. 

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In it, he repeated the tired comparison that Maher was literally having dinner with Hitler and liking it.

“I had been a vocal critic of his on the radio from the beginning, pretty much predicting everything he was going to do on the road to dictatorship,” David wrote in “My Dinner with Adolf,” pretending to tell the story of the dinner from Maher’s perspective. “But eventually I concluded that hate gets us nowhere. I knew I couldn’t change his views, but we need to talk to the other side.”

David went on, “I joked that I was surprised to see him in a tan suit because if he wore that out, it would be perceived as un-Führer-like. That amused him to no end, and I realized I’d never seen him laugh before. Suddenly he seemed so human. Here I was, prepared to meet Hitler, the one I’d seen and heard — the public Hitler. But this private Hitler was a completely different animal. And oddly enough, this one seemed more authentic, like this was the real Hitler. The whole thing had my head spinning.”

“‘I must say, mein Führer, I’m so thankful I came. Although we disagree on many issues, it doesn’t mean that we have to hate each other.’ And with that, I gave him a Nazi salute and walked out into the night,” David’s essay says.

Rosie O’Donnell

And of course, no roundup of Hollywood’s Trump derangement would be complete without the woman who started feuding with him long before he ever entered politics: Rosie O’Donnell.

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The long-running rivalry between Trump and O’Donnell dates back to the 2000s, when “The Apprentice” host and “The View” co-host traded public insults like teenagers. But since Trump’s political rise, O’Donnell has transformed her disdain into an ongoing crusade.

In 2016, she tweeted, “HE WILL NEVER BE PRESIDENT,” in all caps. She also infamously called him an “orange anus” and said, “Donald: Sit and spin, my friend. I don’t enjoy him. No, no, no.”

The comedian lamented Trump’s victory in the 2016 presidential election during a 2017 interview with W Magazine.

“It has taken me a full year to integrate the reality of him being a president in a way that I don’t come across as either so full of rage that no one can hear my words, or so sad that I can’t articulate the level of pain,” O’Donnell told the outlet. “It’s taken a year for me to get my equilibrium back, to come back up to the surface.”

She continued, “I seriously worry whether I personally will be able to live through [his presidency] and whether the nation will be able to live through it and survive. It’s a terrifying concept, on the brink of nuclear war with a madman in charge.”

While many threatened but never followed through, O’Donnell made good on her promise to leave the country if Trump won a second term. She’s currently residing in Ireland.

In the end, Trump benefits from their rage as every insult from a celebrity proves his anti-establishment persona. The more Hollywood freaks out, the more his supporters point out that it doesn’t matter what these ultra-woke, overpaid actors think anyway.

De Niro used to be a legend; now he’s a ranting old man whining about the fairly elected president. Griffin was never that funny, but that severed-head photo ensured that tens of her fans would have a hard time laughing at her ever again. 

All the Trump haters used to influence celebrity culture in some way. Now? They’re spending days shaking their fists at the sky, cursing his second term and every voter who made it possible. 

For them, TDS is a disease with no cure. And even the White House knows it. After joining the left-leaning social media platform Bluesky, they trolled users with a post that said, “Democrats- Rx: Take one pill daily to cure TDS, side effects include putting America First.”

Indeed.

Democrats-

Rx: Take one pill daily to cure TDS, side effects include putting America First.

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— The White House (@whitehouse-47.bsky.social) October 23, 2025 at 8:57 PM